, , , | ICD9 = , |}}Gangrene is the necrosis (cell death) and subsequent decay of body tissue caused by infection or thrombosis (blocked blood vessel). It is usually the result of critically insufficient blood supply (peripheral vascular disease) and is often associated with diabetes and long-term smoking. It is often caused by external injury and subsequent contamination with bacteria. This condition is most common in the lower extremities. The best treatment for gangrene is revascu