, ,
| Name = Glucose-6-phosphate dehydrogenase
| HGNCid = 4057
| Symbol = G6PD
| AltSymbols =; G6PD1
| OMIM = 305900
| ECnumber =
| Homologene = 37906
| MGIid = 105979
| GeneAtlas_image1 = PBB_GE_G6PD_202275_at_tn.png
| Function =
| Component =
| Process =
| Orthologs =
}}
Glucose-6-phosphate dehydrogenase (
G6PD) is an enzyme in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (most notably erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage.
G6PD converts glucose-6-phosphate into 6-phosphoglucono-?-lactone and is the rate-limiting enzyme of the
pentose phosphate pathway.450px|center|Mechanism of G6PD
Glucose-6-phosphate dehydrogenase deficiency is very common worldwide, and cause acute hemolytic anemia in the presence of simple infection, ingestion of fava beans, or reaction with certain medicines, AAA, antibiotics, antipyretics, and antimalarials.
G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. Two transcript variants encoding different isoforms have been found for this gene.
See also
- Glucose-6-phosphate dehydrogenase deficiency
Further reading
