GIST may be: Gist, the central idea or the essence Gwangju Institute of Science and Technology, an R&D university in Gwangju city, South Korea GiST, or Generalized Search Tree, a flexible datastructure for building search trees Gist , a scientific graphics library written in C programming language Gastrointestinal stromal tumor, an uncommon malignancy of the gastrointestinal tract German Institute of Science and Technology, in Singapore