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Nitroxyl (HNO/NO^-) or hyponitrous acid, in chemistry is the reduced form
of nitric oxide (NO). HNO and NO^- form an acid/base pair (pKa = 11.4) with
NO^- isoelectronic with dioxygen. Nitroxyl is very reactive towards
nucleophiles (especially thiols) and quickly dimerizes to H2N2O2 which then
is dehydrated to nitrous oxide N2O.. Therefore, HNO is generally prepared
in situ for example with the compounds such as Angeli?s salt (Na2N2O3) and
Piloty?s acid (PhSO2NHOH) when it is needed.
Nitroxyl shows potential in the treatment of heart failure and ongoing
research is focused on finding new nitroxyl donors. In one study Hydrolysis
of Acyloxy Nitroso Compounds Yields Nitroxyl (HNO) Xin Sha, T. Scott
Isbell, Rakesh P. Patel, Cynthia S. Day, and S. Bruce King J. Am. Chem.
Soc.; 2006
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