| Component = | Process = | Orthologs = }}The melanocortin 1 receptor (also known as melanocyte-stimulating hormone receptor or Mc1r) is one of the key proteins in regulating hair and skin color. A member of the G-protein-coupled receptor family of proteins, it functions at the surface of specialist pigment producing cells (called melanocytes) to regulate melanogenesis in mammals. Protein function Mammalian Mc1r When stimulated by one of the cleavage products of proopiomelanocortin, typically ?-melanocyte stimulating hormone (?-MSH), Mc1r initiates a complex signalling cascade that leads to the production of black or brown eumelanin. In most mammals, this signal can be altered by the binding of another protein to Mc1r. Agouti signalling peptide (Asip), a paracrine signalling factor, anatagonizes ?-MSH activation of Mc1r and results in a switch to the production of re

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