| Name = V-myc myelocytomatosis viral oncogene homolog (avian) | HGNCid =
7553 | Symbol = MYC | AltSymbols =; c-Myc | OMIM = 190080 | ECnumber = |
Homologene = 31092 | MGIid = 97250 | Function = | Component = | Process =
| Orthologs =
}}
Myc (cMyc) is a protooncogene, which is overexpressed in a wide range of
human cancers. When it is specifically-mutated, or overexpressed, it
increases cell proliferation and functions as an oncogene. Myc gene
encodes for a transcription factor that regulates expression of 15% of all
genes Gearhart J, Pashos EE, Prasad MK, Pluripotency Redeux -- advances in
stem-cell researcg, N Engl J Med 357(15):1469 through binding on Enhancer
Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs).
Myc belongs to Myc family of transcription factors, which also includes
N-Myc and L-Myc genes. Myc-family transcription factors contain the
bHLH/LZ (basic Helix-Loop-Helix Leuci
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Myc,