Xerxes may refer to these Persian kings: · Xerxes I, reigned 485–465 BC, also known as Xerxes the Great. · Xerxes II, reigned 424 BC. Xerxes may also refer to: · Xerxes of Armenia, an Armenian king, killed about 212 BC by Antiochus III the Great. · Xerxes of Commagene, third Satrap of the state of Commagene (228 to 201 BC). · Xerxes, an ancient city in the Fullmetal Alchemist manga. · Xerxes (Serse), an opera by George Frideric Handel. · Xerse - Cavalli's earlier opera to the same libretto as Handel's. · Xerxes Frankel, a fictional character in Wili Lieberman's Get Outta Town novel series. · Xerxes , a novel by Louis Couperus. · XERXES, a character in the video game System Shock 2. · Xerxes , a character in Brian Herbert's Legends of Dune universe. · Xerxes , a character in D